Charles Francis Murphy (1890 – 1985) was an American architect based in Chicago, Illinois.
Born in Jersey City, New Jersey, Murphy was educated at the De La Salle Institute in Chicago.
Murphy's first job was as a secretary, joining the offices of D.H. Burnham & Company in 1911, where he was steadily promoted to become personal secretary to the architect Ernest Graham. When Graham died in 1937, Murphy moved on to co-found the architectural practice Shaw, Naess & Murphy, despite that fact that he still had no formal training as an architect. The practice was later renamed C.F. Murphy Associates and then Murphy/Jahn Inc. in 1981 as Helmut Jahn took over as president.
Murphy was awarded an honorary degree from St. Xavier University in 1961, and became a fellow of the American Institute of Architects in 1964.